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The US-based team mapped the cellular changes from normal endometrium to the disease state - endometriosis. Further discovering that the different subgroups had “striking difference in gene expression [molecular signature], adding to a growing body of literature to support that endometriomas and peritoneal lesions are two distinct disease entities”.
These ‘biological road maps’ of cellular change, as well as the unique molecular signatures of the two disease subtypes can now be used by researchers across the world to begin further studies into more personalised therapeutics against endometriosis. Hopefully demystifying the challenging diagnosis and current treatment regime of surgery and hormone therapy, which have varying levels of success.
